Colistin PK-PD (pharmacokinetic-pharmacodynamics) in Indian patients

Pharmacokinetics/Pharmacodynamics (PK/PD) in Designing Effective Antibiotic Treatment Regimens

Designing antibiotic dosing regimens is often not optimal and the dose-response relationship for most antibiotics is not well-known1. Both Pharmacokinetics (PK) and Pharmacodynamics (PD) are characteristics of antimicrobial agents that should be considered in the development of effective antibiotic therapy. By linking the concentration time profile at the site of action to the drug effect (PK/P...

In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis

BACKGROUND Haemophilus parasuis (H. parasuis) causes Glässer's disease and multisystem infectious disease. It is one of the major causes of nursery mortality in swine herds. Cefquinome (CEQ) is proposed for the treatment of pigs against respiratory tract infection. However, few studies have investigated the PK/PD characteristics and PK/PD cutoff of this drug against H. parasuis. RESULTS A tot...

Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents

Pharmacokinetic (PK) Characteristics in Critically Ill Patients

Stochastic PK/PD Modelling

This thesis describes the development of a software prototype implemented in Matlab for non-linear mixed effects modelling based on stochastic differential equations (SDEs). The setup aims at modelling measurements originating from more than one individual and it represents a powerful way of modelling systems with complicated and partially unknown dynamics. The incorporation of SDEs enables the...